| 炎性体与器官移植 |
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| 引用本文： | 刘慧,陈建忠.炎性体与器官移植[J].国外医学：分子生物学分册,2011(3):269-272. |
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| 作者姓名： | 刘慧 陈建忠 |
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| 作者单位： | 浙江大学医学院免疫学研究所,杭州市310058 |
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| 基金项目： | 国家重点基础研究发展计划项目（973计划）（No.2009CB522402） |
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| 摘 要： | 炎性体是指存在于细胞质内能够激活半胱天冬酶-1（caspase-1）的大分子复合物,活化的caspase-1通过酶切白细胞介素-1β（IL-1β）和白细胞介素-18（IL-18）前体分子而生成具有生物学活性的IL-1β和IL-18.近来研究发现,炎性体分子NLRP1、NLRP2、NLRP5、CARD8、CASP5的基因型与移植的临床结果相关,心脏移植排斥反应时ASC和IL-1β的表达升高,缺血再灌注损伤中NLRP3炎性体激活增加IL-1β分泌,表明炎性体的激活与移植排斥反应和缺血再灌注损伤密切相关,但诱导炎性体活化的配体和参与的炎性体分子有待进一步研究.
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| 关 键 词： | 炎性体 半胱天冬酶-1 白细胞介素-1β 器官移植 |
Inflammasomes and Organ Transplantation |
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| Authors: | LIU Hui CHEN Jianzhong |
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| Institution: | (Institute of Immunology, Medical College of Zhejiang University, Hangzhou, 310058, China) |
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| Abstract: | Inflammasome is a cytoplasmic multi-molecule complex, which activates casepase-1 and the activated easepase-1 then processes the secreted cytokines interleukin-1β （IL-1β） and intedeukin-18 （IL-18） . Recent studies have shown that the genotype of NLRP1, NLRP2, NLRPS, CARD8 and CASP5 is related to the clinical outcome of transplantation. The levels of ASC and IL-1β expression are increased in rejection reaction of cardiac transplantation in mice. Activated NLRP3 inflammasome and elevated IL-1β were observed in ischemia-reperfusion injury. These results indicate that activation of inflammasome is closely related to graft rejection and ischemia-reperfusion injury. The ligands and molecules involved in inflammasome need to be further investigated. |
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| Keywords: | inflammasome caspase-1 interleukin-1β organ transplantation |
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