| 硫酸肝素与甲病毒感染 |
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| 引用本文： | 朱武洋,李江姣,梁国栋.硫酸肝素与甲病毒感染[J].国外医学：分子生物学分册,2011(4):340-344. |
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| 作者姓名： | 朱武洋 李江姣 梁国栋 |
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| 作者单位： | 中国疾病预防控制中心病毒病预防控制所传染病预防控制国家重点实验室,北京市100052 |
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| 基金项目： | 国家自然科学基金（No.30970160）,“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（No.2008ZX10004-001;2009ZX10004-705） |
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| 摘 要： | 硫酸肝素存在于细胞膜表面、基底膜及细胞外基质，是一种高度硫酸化的、带负电荷的多糖结构。研究表明辛德毕斯病毒等甲病毒可通过与细胞表面的硫酸肝素结合进入宿主细胞，完成对细胞的感染。提示细胞表面的硫酸肝素是甲病毒感染细胞的受体或共受体。
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| 关 键 词： | 硫酸肝素 受体 甲病毒 细胞感染 |
Correlation between Heparan Sulfate and Alphavirus Infection |
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| Authors: | ZHU Wuyang LI Jiangjiao LIANG Guodong |
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| Institution: | (State Key Laboratory for Infectious Disease Prevention and Control, Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100052, China) |
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| Abstract: | Heparan sulfate （HS） is a group of polyanionic carbohydrate chains expressed on the cell surfaces, in the cell membranes and extracellular matrix. HS has also been demonstrated to function as receptors or co-receptors for a number of different viruses, including alphaviruses, sueh as sindbis virus that ean infect host cells by binding with HS on cell surface. Here, we mainly review the biologieal characteristics of HS and its roles in alphaviruses infeetion. |
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| Keywords: | heparan sulfate receptors alphavirus cell infection |
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