| Obestatin、Ghrelin与血糖调节 |
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| 引用本文： | 孙杰辉[综述],吴汉妮[审阅].Obestatin、Ghrelin与血糖调节[J].国外医学：分子生物学分册,2011(6):547-550. |
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| 作者姓名： | 孙杰辉[综述] 吴汉妮[审阅] |
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| 作者单位： | 华中科技大学同济医学院附属协和医院内分泌科,武汉市430022 |
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| 摘 要： | 肥胖抑制素（obestatin）和生长激素释放肽（ghrelin）能互相拮抗,参与血糖的调节.其中obestatin与GPR-39（G-protein-coupled receptor 39）结合抑制摄食和胃肠排空、促进胰岛β细胞功能,影响胰岛素的分泌;而ghrelin与生长激素促分泌受体（GHSR1a）结合,促进食欲和胃肠排空,减少脂肪的利用,抑制胰岛细胞凋亡,调节胰岛素的分泌.但两者参与血糖调节的具体机制尚存在争议.
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| 关 键 词： | 肥胖抑制素 生长激素释放肽 血糖调节 |
Obestatin and Ghrelin in Regulation of Blood Glucose |
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| Institution: | SUN Jiehui Department of Endocrinology of Wuhan Union Hospital, Huazhong University of Science ＆ Technology, Wuhan, 430022, China |
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| Abstract: | Obestatin and ghrelin participate and antagonize each other in blood glucose regula- tion. Obestatin inhibits food intake, gastrointestinal evacuation and motility, and increases insulin secretion from pancreatic β-cells, whereas ghrelin enhances appetite, gastrointestinal emptying and motility, decreases fat consumption, prevents apoptosis of pancreatic β-cells and human islets thereby controlling insulin secretion. However, the mechanisms of both obestatin and ghrelin in blood glucose regulation remain controversial. |
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| Keywords: | obestatin ghrelin regulation of blood glucose |
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