炎性体及其在流感病毒感染过程中的作用

炎性体是胞液中感受危险信号、启动介导下游免疫防御或细胞死亡（pyroptosis）的多分子复合物,是细胞内天然免疫的重要受承信号转导的中介体.炎性体识别流感病毒后诱导先天免疫反应甚至pyroptosis样细胞死亡.流感病毒高尔基体表达的M2蛋白和P2X7、ATP、ROS在炎性体的调节过程中发挥了重要作用,微生物也可以通过激活炎性体调节呼吸道粘膜免疫.炎性体的提出为最优疫苗的设计提供了新的思路.

Inflammasome and Its Role in the Influenza Virus Infection

Inflammasome is a macromolecular protein complex, which senses intracellular danger signal, aclivates and mediates subsequent immune defense or pyroptosis, thereby functioning as a medialol： in signal transduction in innate immune system. Upon recognizing influenza virus, inflam- masome induces innate immune reaction and even pyroptosis. M2 protein that is expressed by influenza virus in the Golgi body, P2X7, ATP and ROS are important inflammasome regulalots. Mierobiota can also regulate mucous immunization of respiratory tract by activating inflammasome. The introduction of inflammasome provides a novel approach to designing optimal vaccine efficacy.