Dynamic properties of interaction between nucleic acid bases and models of amino acids |
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Authors: | B S Yu D H Sohn G Goo |
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Institution: | Laboratory of Physical Pharmacy, College of Pharmacy, Seoul National University, Korea. |
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Abstract: | We have discussed the possible hydrogen bonding mode of adenine-uracil base dimers and peptide side chains, together with their characteristic effects on the stability of adenine-uracil base pairing in chloroform solution by using proton nuclear magnetic resonance methods, where acetamide and butyric acid were used as a model of residues of glutamine and glutamic acid, respectively, and were added to an adenine-uracil equimolar mixture. The stability of base pairing was affected significantly when the model compounds approached the adenine-uracil base pairs; that is, the Hoogsteen type was destroyed, while the Watson-Crick type was formed more favorably. |
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