Functional dissection of translocon proteins of the <Emphasis Type="Italic">Salmonella</Emphasis> Pathogenicity Island 2-encoded type III secretion system |
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Authors: | Stefanie U Hölzer Michael Hensel |
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Institution: | 1.Mikrobiologisches Institut,Universit?tsklinikum Erlangen,Erlangen,Germany |
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Abstract: | Background Type III secretion systems (T3SS) are essential virulence factors of most Gram-negative bacterial pathogens. T3SS deliver
effector proteins directly into the cytoplasm of eukaryotic target cells and for this function, the insertion of a subset
of T3SS proteins into the target cell membrane is important. These proteins form hetero-oligomeric pores acting as translocon
for the delivery of effector proteins. Salmonella enterica is a facultative intracellular pathogen that uses the Salmonella Pathogenicity Island 2 (SPI2)-encoded T3SS to manipulate host cells in order to survive and proliferate within the Salmonella-containing vacuole of host cells. Previous work showed that SPI2-encoded SseB, SseC and SseD act to form the translocon of
the SPI2-T3SS. |
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