Assessment of decorin-binding protein A to the infectivity of <Emphasis Type="Italic">Borrelia burgdorferi</Emphasis> in the murine models of needle and tick infection

Background  

Decorin-binding proteins (Dbps) A and B of Borrelia burgdorferi, the agent of Lyme disease, are surface-exposed lipoproteins that presumably bind to the extracellular matrix proteoglycan, decorin. B. burgdorferi infects various tissues including the bladder, heart, joints, skin and the central nervous system, and the ability of B. burgdorferi to bind decorin has been hypothesized to be important for this disseminatory pathogenic strategy.