A first insight into the genetic diversity of Mycobacterium tuberculosis in Dar es Salaam, Tanzania, assessed by spoligotyping |
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| Authors: | Vegard Eldholm Mecky Matee Sayoki GM Mfinanga Manfred Heun and Ulf R Dahle |
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| Institution: | (1) Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway;(2) Institute of Nature Resource Management, Norwegian University of Life Sciences, Norway;(3) Muhimbili Medical Research Centre, Dar es Salaam, Tanzania |
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| Abstract: | Background Tanzania has a high tuberculosis incidence, and genotyping studies of Mycobacterium tuberculosis in the country are necessary in order to improve our understanding of the epidemic. Spoligotyping is a potentially powerful
genotyping method due to fast generation of genotyping results, high reproducibility and low operation costs. The recently
constructed SpolDB4 database and the model-based program 'spotclust' can be used to assign isolates to families, subfamilies
and variants. The results of a study can thus be analyzed in a global context. |
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