Autoinducer production and quorum-sensing dependent phenotypes of <Emphasis Type="Italic">Pseudomonas aeruginosa</Emphasis> vary according to isolation site during colonization of intubated patients |
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| Authors: | Sabine Favre-Bonté Eric Chamot Thilo Köhler Jacques-A Romand Christian van Delden |
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| Institution: | 1.Service des Maladies Infectieuses,H?pital Universitaire de Genève,Genève 14,Switzerland;2.Department of Epidemiology,University of Alabama,Birmingham,USA;3.Service des Soins Intensifs,H?pital Universitaire de Genève,Genève,Switzerland;4.UMR CNRS 5557-Ecologie Microbienne,Université Claude Bernard,Lyon 1,France |
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| Abstract: | Background
Pseudomonas aeruginosa frequently colonizes and is responsible for severe ventilator-associated pneumonia in intubated patients. A quorum-sensing
(QS) circuit, depending on the production of the two QS-signaling molecules (autoinducers, AIs) 3-oxo-C12-HSL and C4-HSL, regulates the production by P. aeruginosa of several virulence factors and is required for biofilm formation. Therefore QS-inhibition has been suggested as a new target
for preventive and/or therapeutic strategies. However the precise role of QS during colonization and subsequent infections
of intubated patients remains unclear. |
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