Helicases and RNA unwinding in translation: Current opinion in structural biology 1993, 3: 953–959 |
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Authors: | Arnim Pause Nahum Sonenberg |
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Abstract: | RNA helicases melt regions of duplex RNA in a process that requires energy derived from the hydrolysis of nucleoside triphosphates. The process of protein synthesis in prokaryotes and eukaryotes involves one proven RNA helicase (elF-4A) and several putative RNA helicases. Of these, one group of helicases is thought to unwind secondary structure in the 5′ non-coding region of mRNAs to facilitate ribosome binding. A second group is implicated in ribosome assembly, in particular in ribosomal RNA maturation. |
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