| 基于设计的生物大分子成药性优化策略研究进展 |
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| 引用本文： | 田浤,尹俊,戴鑫,宁宏宇,陈松,高向东,姚文兵.基于设计的生物大分子成药性优化策略研究进展[J].微生物学杂志,2015(4). |
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| 作者姓名： | 田浤 尹俊 戴鑫 宁宏宇 陈松 高向东 姚文兵 |
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| 作者单位： | 中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009,中国药科大学生命科学与技术学院, 江苏 南京 210009 |
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| 基金项目： | 国家自然科学基金（No. 81430082）;中央高校基本科研
业务费重大研究计划引导项目（No. YD2014SK0002） |
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| 摘 要： | 目前生物药物正处在高速发展阶段,但生物大分子的一些固有特性限制了其成药性,使得很多具有良好治疗潜能的生物大分子
最终不能开发成药物,因而严重制约了生物药物的发展。生物药物开发的瓶颈已从“新分子的产生”转向“如何获得具有优良生理特性
和预期治疗效果的有效药物”。近年来,通过合理设计改造生物大分子高级结构以优化其成药性的研究获得了快速发展。综述基于设计
的生物大分子成药性优化策略研究进展。
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| 关 键 词： | 生物大分子 成药性 合理设计 |
Advances in Research on Design-based Optimization Strategy for the Drugability of Biological Macromolecules |
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| TIAN Hong,YIN Jun,DAI Xin,NING Hongyu,CHEN Song,GAO Xiangdong and YAO Wenbing.Advances in Research on Design-based Optimization Strategy for the Drugability of Biological Macromolecules[J].Journal of Microbiology,2015(4). |
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| Authors: | TIAN Hong YIN Jun DAI Xin NING Hongyu CHEN Song GAO Xiangdong and YAO Wenbing |
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| Institution: | School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China,School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China,School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China,School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China,School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China,School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China and School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Biological medicines are in rapid development stage for now. However, some inherent characteristics of biological macromolecules
restricts their drugability, so that a lot of biological macromolecules with therapeutic potential fail to be eventually developed into drugs. As a result,
the development of biological medicines was seriously restricted. Bottleneck of biological medicine development has shifted from "the generation of
new molecular" to "how to get a good physiological characteristics and the expected treatment effect of effective drug". In recent years, the research
on reconstruction of biological macromolecular structures by rational design to optimize their drugability has developed rapidly. In this paper, the
research progress on design-based optimizaion strategy for the drugability of biological macromolecules was reviewed. |
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| Keywords: | biological macromolecule drugability rational design |
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