| 吡咯并[4,3,2-de]喹啉类天然产物的研究进展 |
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| 引用本文： | 亓晨晓,杨圣伟,孙丽萍.吡咯并[4,3,2-de]喹啉类天然产物的研究进展[J].微生物学杂志,2015(1). |
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| 作者姓名： | 亓晨晓 杨圣伟 孙丽萍 |
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| 作者单位： | 中国药科大学药物化学教研室，江苏 南京 210009,中国药科大学药物化学教研室，江苏 南京 210010,中国药科大学药物化学教研室，江苏 南京 210011 |
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| 基金项目： | 国家自然科学基金资助项目（No. 21472243） |
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| 摘 要： | 吡咯并4,3,2-de ]喹啉类生物碱是从蟾蜍以及海洋生物等中提取出来的次级代谢物，具有抗寄生虫、抗病毒、抗肿瘤等多种生物活
性，是一类有成药潜力的天然产物。综述部分吡咯并4,3,2-de ]喹啉类天然产物的生物活性、生物合成以及化学合成的研究进展，并对其现
存问题和发展方向进行分析和展望。
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| 关 键 词： | 吡咯并[4 3 2-de ]喹啉 生物碱 天然产物 次级代谢物 抗肿瘤活性 合成 |
Research Progress of Natural Products Based on Pyrrolo[4,3,2-de]quinoline Skeleton |
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| QI Chenxiao,YANG Shengwei and SUN Liping.Research Progress of Natural Products Based on Pyrrolo[4,3,2-de]quinoline Skeleton[J].Journal of Microbiology,2015(1). |
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| Authors: | QI Chenxiao YANG Shengwei and SUN Liping |
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| Institution: | Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China,Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210010, China and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210011, China |
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| Abstract: | Pyrrolo4,3,2- de ]quinoline alkaloids are a series of secondary metabolites which are isolated from toads, marine organisms, etc.
possessing significant physiological activities of anti-parasite, antivirus, anti-tumor and so on, thus having the potential of being developed into drugs.
In this paper, some recent progress on bioactivities, biosynthesis and chemosynthesis of part of these compounds are mainly reviewed. The problems
and prospects of such natural products are also provided |
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| Keywords: | pyrrolo[4 3 2- de ]quinoline alkaloid natural product secondary metabolite anti-tumor activity synthesis |
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