| 多标记物法在心力衰竭风险评估中的应用 |
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| 引用本文： | 严颐丹,江慧勇,王艺璇,何华,柳晓泉.多标记物法在心力衰竭风险评估中的应用[J].微生物学杂志,2015(1). |
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| 作者姓名： | 严颐丹 江慧勇 王艺璇 何华 柳晓泉 |
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| 作者单位： | 中国药科大学药物代谢与动力学研究中心，江苏 南京 210009,中国药科大学药物代谢与动力学研究中心，江苏 南京 210010,中国药科大学药物代谢与动力学研究中心，江苏 南京 210011,中国药科大学药物代谢与动力学研究中心，江苏 南京 210012,中国药科大学药物代谢与动力学研究中心，江苏 南京 210013 |
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| 摘 要： | 心力衰竭的发生发展涉及多条生理病理通路，选择不同通路中的多个生物标记物能够提高对心力衰竭风险评估的准确性。总结了心
力衰竭发生发展过程中与心肌损伤、内皮功能障碍、神经激素紊乱、炎症反应、氧化应激过程相关的生物标记物，基于多标记物评价方法
的数学模型及多标记物法在心力衰竭和药物心脏毒性风险评估中的应用。
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| 关 键 词： | 多标记物法 心力衰竭 风险评估 生物标记物 |
Application of Multimarker Approach in Risk Assessment for Heart Failure |
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| YAN Yidan,JIANG Huiyong,WANG Yixuan,HE Hua and LIU Xiaoquan.Application of Multimarker Approach in Risk Assessment for Heart Failure[J].Journal of Microbiology,2015(1). |
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| Authors: | YAN Yidan JIANG Huiyong WANG Yixuan HE Hua and LIU Xiaoquan |
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| Institution: | Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China,Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210010, China,Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210011, China,Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210012, China and Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210013, China |
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| Abstract: | As a complex disease, heart failure is related to diverse pathophysiological pathways which can be assessed by several biomarkers.
Combined use of these biomarkers could better assess the risk in heart failure. The biomarkers in pathophysiological pathways such as myocardial
injury, endothelial dysfunction, neurohormone disorder, inflammation and oxidative stress in the progress of heart failure,mathematical models for
multimarker analysis, as well as multimarker approach for risk assessment in heart failure and cardiotoxicity of drugs have been summarized in this
paper. |
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| Keywords: | multimarker approach heart failure risk assessment biomarker |
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