| 生物活性肽-蛋氨酸脑啡肽对成骨细胞增殖的影响 |
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| 引用本文： | 薛明,高阳,杨谛,仇丽鸿.生物活性肽-蛋氨酸脑啡肽对成骨细胞增殖的影响[J].微生物学杂志,2011,31(2):89-91. |
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| 作者姓名： | 薛明 高阳 杨谛 仇丽鸿 |
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| 作者单位： | 1. 中国医科大学口腔医学院牙体牙髓科,辽宁省口腔医学研究所牙体牙髓病研究室,辽宁,沈阳,110002
2. 沈阳市铁西区中心医院,口腔科,辽宁,沈阳,110021 |
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| 摘 要： | 蛋氨酸脑啡肽（Methionine Enkephalin,MENK）作为内源性物质,通过与阿片受体结合,发挥阿片样物质的生物学作用。研究表明,MENK在成熟的骨组织和成骨细胞中均有分布,并且在成骨细胞表面发现了阿片受体。实验旨在进一步研究MENK对成骨细胞增殖的影响。体外培养MC3T3-E1成骨细胞,MTT方法检测MENK对成骨细胞增殖的影响。结果表明,10-7、10-8、10-9mol/L的MENK对成骨细胞的增殖具有促进作用（P〈0.05）。提示MENK可在骨缺损疾病中发挥促进骨组织重建的作用。
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| 关 键 词： | 蛋氨酸脑啡肽 成骨细胞 增殖 |
Effect of Bio-Active Peptide-Methionine Enkephalin (MEK) on Proliferation of Osteoblast |
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| XUE Ming,GAO Yang,YANG Di,QIU Li-hong.Effect of Bio-Active Peptide-Methionine Enkephalin (MEK) on Proliferation of Osteoblast[J].Journal of Microbiology,2011,31(2):89-91. |
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| Authors: | XUE Ming GAO Yang YANG Di QIU Li-hong |
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| Institution: | XUE Ming1,GAO Yang2,YANG Di1,QIU Li-hong1(1.Dept.of Endodont.,Coll.of Stomat.,China Med.Uni.,Shenyang 110002,2.Dept.of Stomat.,Ctrl Hosp.of Tiexi Dist.in Shenyang city,Shenyang110021) |
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| Abstract: | Methionine-enkephalin(MEK),as an endogenous substance,could play biological role of opium-like substance through binding to opiate receptors.Studies suggested that MEK are distributed in mature bone tissue and osteoblast and opium receptors were found on osteoblast' surface.This experiment aimed at further study on the effect of MEK on the proliferation of osteoblast.The MC3T3-E1 cells were cultured in vitro.The cell proliferation was detected by MTT assay.The results exhibited that some concentration of ME... |
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| Keywords: | methionine-enkephalin(MEK) osteoblast proliferation |
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