| 阿霉素靶向给药系统研究进展 |
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| 引用本文： | 李进典,洪杏芳,张健,殷志琦,顾觉奋.阿霉素靶向给药系统研究进展[J].微生物学杂志,2014,38(12). |
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| 作者姓名： | 李进典 洪杏芳 张健 殷志琦 顾觉奋 |
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| 作者单位： | 中国药科大学中药学院，江苏 南京 210009,大理学院公共卫生学院，云南 大理 671000,江苏省中医药研究院转化医学实验室，江苏 南京 210028,中国药科大学中药学院，江苏 南京 210009,中国药科大学生命科学与技术学院，江苏 南京 210009 |
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| 摘 要： | 近年来，癌症的发病率和死亡率不断上升，对人类健康造成极大的威胁。阿霉素作为一种广谱抗肿瘤药物，对正常细胞亦有严重毒副作用，从而使其临床应用受到限制。提高阿霉素肿瘤靶向性、降低其毒性由此成为该药物的热点研究方向。对阿霉素靶向给药系统的研究进展进行了综述。
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| 关 键 词： | 阿霉素 抗肿瘤 靶向给药系统 |
Advances in Research on Targeting Drug Delivery System of Doxorubicin |
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| LI Jindian,HONG Xingfang,ZHANG Jian,YIN Zhiqi and GU Juefen.Advances in Research on Targeting Drug Delivery System of Doxorubicin[J].Journal of Microbiology,2014,38(12). |
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| Authors: | LI Jindian HONG Xingfang ZHANG Jian YIN Zhiqi and GU Juefen |
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| Institution: | School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China;,School of Public Health, Dali University,Dali 671000, China;,Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China;,School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 210009, China; and School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | In recent years, the morbidity and mortality of cancer have been rising, which has become a great threat to human health. Doxorubicin is a broad-spectrum antitumor drug. It also has serious side effects on the normal cells, which limits its clinical application. Increase tumor targeting effect and reducing the toxicity have become a hot research direction of this drug. The advances in research on targeting drug delivery system of doxorubicin have been reviewed in this paper. |
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| Keywords: | doxorubicin antitumor targeting drug delivery system |
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