| 牡丹皮水煎剂对体外白念珠菌生物膜的抑制作用 |
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| 引用本文： | 汪长中,程惠娟,官妍,张祝,郭峰,丁超.牡丹皮水煎剂对体外白念珠菌生物膜的抑制作用[J].微生物学杂志,2009,29(2):67-70. |
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| 作者姓名： | 汪长中 程惠娟 官妍 张祝 郭峰 丁超 |
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| 作者单位： | 安徽中医学院,中西医结合临床学院,安徽,合肥,230038 |
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| 基金项目： | 安徽省自然科学基金，安徽省高等学校自然科学基金 |
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| 摘 要： | 研究牡丹皮水煎剂对体外白念珠菌生物膜的影响。体外构建白念珠菌生物膜并采用XTT减低法评价牡丹皮水煎剂对白念珠菌成熟生物膜影响以及包被生物材料对白念珠菌生物膜形成的影响。结果显示，牡丹皮水煎荆对白念珠菌悬浮菌MIC为1．56mg／mL；对白念珠菌生物膜SMIC50与SMIC50分别是3．12和6．25mg／mL；药物包被96孔板对白念珠菌生物膜形成有一定的抑制效应。实验表明牡丹皮水煎剂对体外白念珠菌生物膜有较强抑制作用。
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| 关 键 词： | 牡丹皮水煎剂 白念珠菌 生物膜 |
Inhibition Effects of Aqueous Decoction of Peony Radices Cortex on Candida albicans Biofilm in vitro |
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| WANG Chang-zhong,CHENG Hui-juan,GUAN Yan,ZHANG Zhu,GUO Feng,DING Chao.Inhibition Effects of Aqueous Decoction of Peony Radices Cortex on Candida albicans Biofilm in vitro[J].Journal of Microbiology,2009,29(2):67-70. |
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| Authors: | WANG Chang-zhong CHENG Hui-juan GUAN Yan ZHANG Zhu GUO Feng DING Chao |
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| Institution: | ( Sch. of Combined Tradit＇ l Chinese and West. Med. , Anhui Coll. of Tradit＇ l Med. , Hefei 230038 ) |
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| Abstract: | The effects of aqueous decoction of peony radices cortex （ ADPRC ） on C. albicans＇ biofilm （ CAB ） in vitro were studied. CAB was constructed in vitro and XTT reduction assay was adopted to evaluate the effects of ADPRC on mature CAB, and the effects of coating biomaterials with ADPRC on CAB formation. The results showed that the minimal inhibitory concentration （MIC） values of ADPRC against suspended C. albicans was 1.56 mg/mL, and SMIC （SMIC50, SMIC50） values of the agent against biofilm （sessile） C. albicans were 3.12 mg/mL and 6.25mg/ mL respectively. The coating of biomaterials with ADPRC of 96 porous board had a certain inhibitory effects on subsequent biofilm development by C. albicans in vitro. This experiment indicated that ADPRC had fairly strong inhibition against CAB in vitro. |
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| Keywords: | aqueous decoction of peony radices cortex （ ADPRC ） Candida albicans biofilm |
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