人源乳酸菌对2型糖尿病小鼠的缓解效果

为考察人源乳酸菌(发酵乳杆菌Lactobacillus fermentum 11、305和植物乳杆菌 Lactobacillus plantarum 22、25)对2型糖尿病的缓解效果，对2型糖尿病小鼠连续灌胃菌粉溶液12周。每周记录各组小鼠体重、进食量和血糖。实验结束前进行口服葡萄糖耐量试验和胰岛素抵抗试验。实验结束后检测血清中血脂指标，包括总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白。结果显示，经过菌粉溶液灌胃后的2型糖尿病小鼠血糖、进食量、低密度脂蛋白、总胆固醇和甘油三酯显著降低（P<0.05）,葡萄糖耐量和胰岛素抵抗能力显著提高（P<0.05），体重无显著性变化，高密度脂蛋白增加但不显著。几株人源乳酸菌对2型糖尿病小鼠有缓解效果，为后续深入研究提供参考。

Relieving Effects of Human Origin Lactobacillus to Type 2 Diabetes

The relieving effects of human origin Lactobacillus (L. fermentum 11, L. fermentum 305, L. plantarum 22, and L. plantarum 25) to type 2 diabetes were studied. In this study mice with type 2 diabetes were given a solution of bacteria powder of the human origin Lactobacillus continuously for 12 weeks. The weight, food intake and blood glucose of each group of mice were recorded every week. Before the end of the experiment, an oral glucose tolerance test and an insulin resistance test were performed. The blood lipid indexes in the serum were detected, including total cholesterol, triglycerides, high-density lipoprotein and low-density lipoprotein after the experiment was ended. The results showed that the blood glucose, food intake, low-density lipoprotein, total cholesterol, and triglycerides of type 2 diabetic mice after intragastric administration of the bacterial powder solution were significantly reduced (P<0.05), and glucose tolerance and insulin resistance were significantly improved (P<0.05). There was no significant change in both body weight, and high-density lipoprotein increased but not significantly though. So alleviating effects on type 2 diabetic mice was improved by the powder of human origin Lactobacillus (L. fermentum 11, L. fermentum 305, L. plantarum 22, and L. plantarum 25), providing a theoretical basis for subsequent in-depth research.