RLRs介导的抗鲤春病毒血症病毒作用研究进展

鲤春病毒血症病毒(SVCV)是水生动物病毒中重要的病原体,常引起鲤科鱼类疾病暴发。近些年研究发现,维甲酸诱导基因I样受体家族(RLRs)信号通路在SVCV免疫过程中起到重要的作用。主要功能是在识别病原体相关模式,激活下游信号分子,诱导天然免疫的产生,以及控制病毒的早期复制。当病毒进入机体时会形成病毒-RLRs-IFN互联反馈回路,RLRs相关基因识别SVCV的RNA,最终引起Ⅰ型干扰素(IFN-I)表达量升高,并且RLRs族内成员相互作用增强抗病毒作用。RLRs不仅可以活化天然免疫信号通路,还可增强适应性免疫效应,在控制病毒感染过程中发挥重要作用。介绍RLRs家族,RLRs抗病毒信号调控因子,干扰素诱导的鱼类Mx (myxovirus resistant)蛋白对鲤春病毒血症病毒的抑制作用。

Advances in RLRs Mediated Antiviral Viremia against Spring Carp Virus

Spring viremia of carp virus (SVCV) is an important pathogen in aquatic animal viruses, often causing the outbreak of cyprinid diseases. It was found in recent years, that retinoic acid induced gene I like receptor family (RLRs) signaling pathway plays an important role in the SVCV immune process. The primary function is to identify pathogen associated patterns, activate downstream signaling molecules, induce the production of natural immunity, and control early replication of the virus. When the virus enters the body, a virus RLRs IFN interconnection feedback loop is formed, and the RLRs related genes recognize the SVCV RNA, which eventually causes the expression of type I interferon (IFN I) to increase. And members of the RLRs family interact to enhance antiviral effects. RLRs not only activate the natural immune signaling pathway, but also enhance adaptive immune effects and play an important role in controlling viral infection. This paper introduced the inhibitory effects of the RLRs family, RLRs antiviral signaling regulators, and interferon induced fish Mx (myxovirus resistant) proteins on spring viremia of carp virus.