| 抗高脂血症:新靶点与新药研发 |
| |
| 引用本文： | 阮文臣.抗高脂血症:新靶点与新药研发[J].微生物学杂志,2017(1). |
| |
| 作者姓名： | 阮文臣 |
| |
| 作者单位： | 1. 中国药科大学江苏省新药筛选重点实验室,天然药物活性组分与药效国家重点实验室,江苏 南京 210009; 2. 中国科学院上海药物研究所
国家新药筛选中心,上海 201203 |
| |
| 基金项目： | 国家自然科学基金青年基金项目(No. 21402241);天然
药物活性组分与药效国家重点实验室(中国药科大学)开放课题(No.
SKLNMKF201407) |
| |
| 摘 要： | 高脂血症是引发各种心脑血管疾病最主要的因素之一,通过调节血脂来降低心脑血管疾病的发生率,具有重大意义。从调控内 源性脂质合成、外源性脂质吸收与胆汁酸重吸收、血浆脂蛋白代谢以及脂质代谢等 4 个方面出发,系统概述抗高脂血症的新靶点与新药 研究进展,旨在为高脂血症的治疗药物开发提供参考。
|
| 关 键 词： | 高脂血症 胆固醇 三酰甘油 脂质代谢 药物靶点 新药研发 |
Anti-hyperlipidemia: New Targets and New Drugs |
| |
| RUAN Wenchen.Anti-hyperlipidemia: New Targets and New Drugs[J].Journal of Microbiology,2017(1). |
| |
| Authors: | RUAN Wenchen |
| |
| Institution: | Hyperlipidemia is one of the major factors causing various cardio-cerebrovascular diseases(CCVD). As a result, it is of great signi cance to reduce CCVD incidence by regulating blood lipid. In this paper, the research progress in new targets and new drugs against hyperlipidemia was reviewed from four aspects: the regulation of endogenous lipid synthesis, exogenous lipid absorption and bile acid absorption, plasma lipoprotein metabolism and lipid metabolism, in order to provide references for the development of new therapies for hyperlipidemia. |
| |
| Abstract: | Hyperlipidemia is one of the major factors causing various cardio-cerebrovascular diseases(CCVD). As a result, it is of great signi cance to reduce CCVD incidence by regulating blood lipid. In this paper, the research progress in new targets and new drugs against hyperlipidemia was reviewed from four aspects: the regulation of endogenous lipid synthesis, exogenous lipid absorption and bile acid absorption, plasma lipoprotein metabolism and lipid metabolism, in order to provide references for the development of new therapies for hyperlipidemia. |
| |
| Keywords: | hyperlipidemia cholesterol triglyceride lipid metabolism drug target drug discovery |
|
| 点击此处可从《微生物学杂志》浏览原始摘要信息 |
| 点击此处可从《微生物学杂志》下载免费的PDF全文 |
