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Rational use of Jatropha curcas L. in food and medicine: from toxicity problems to safe applications |
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| Authors: | Muhamad Insanu Chryssa Dimaki Richard Wilkins John Brooker Piet van der Linde Oliver Kayser |
| Institution: | 1. Department of Pharmaceutical Biology, University of Groningen, Antonius Deusinglaan 1, 9713 AV, Groningen, The Netherlands 2. School of Pharmacy, Institut Teknologi Bandung, Jalan Ganesa 10, Bandung, Indonesia 3. School of Agriculture Food and Rural Development, University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK 4. Quinvita NV, Derbystraat 71, 9051, St Denijs Westrem, Ghent, Belgium 5. Technical Biochemistry, Technical University Dortmund, Emil-Figge-Strasse 66, Dortmund, Germany |
| Abstract: | Jatropha curcas L. has become an important plant for biorefinery and production of biodiesel. From its ethnobotanical use, the plant is known for several activities which are associated with high toxicity. The latest development in engineering technology enables detoxification of native oil and other parts of the plant for new pharmaceutical purposes. Hence a revised look to the rich metabolic spectra of partly structurally rare secondary compound becomes an interesting field of research to be explored. In this review, we discuss recent developments in the technology of detoxification process and give insight about how this ethnomedicinal plant can be applied to new fields of experimental medicine. The review highlights recent data on biological activities and discusses concepts and strategies for turning a poison plant into a valuable crop with high pharmaceutical potential. |
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