Chemotaxonomy studies on the genus Hedysarum |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China;2. National Institutes for Food and Drug Control, Beijing, 102629, China;3. Guangzhou Welman New Drug R&D CO., LTD, Guangzhou, 510620, China;4. School of Chinese Medicine, Hong Kong Baptist University, Hongkong, China;1. Central Analítica - Centro de Apoio Multidisciplinar (CAM), Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;2. Centro de Biotecnologia da Amazônia, 69075-351, Manaus, AM, Brazil;3. Departamento de Química, Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;1. Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi''an 710032, China;2. Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi''an, 710032, China;3. College of Pharmacy, Shaan''xi University of Chinese Medicine, Xi''an, 712046, China;1. Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, #1 Weigang, Nanjing, 210095, Jiangsu Province, PR China;2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, #4655 Daxue Road, Jinan, 250355, Shandong Province, PR China;3. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, PR China;4. Jiangsu Vocational College of Agricultural and Forestry, Zhenjiang, 212400, Jiangsu Province, PR China;1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115, MA, USA;2. Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany;3. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany;4. Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia |
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| Abstract: | In combination with phytochemical results, the pilot chemotaxonomy study on genus Hedysarum by using HPLC methods revealed differences between section Fruticosa and the three other sections Multicaulia, Obscura and Subacaulia, but there was a closer genetic relationship with Multicaulia and Subacaulia. Isoflavonoids and pterocarpans were proved to be the common constituents of genus Hedysarum, whereas pterocarpans, benzofurans, and coumestans were the characteristic constituents of section Fruticosa, and chalcones were the chemical markers of section Multicaulia and section Subacaulia. The present finding is consistent with the classical morphological classification of genus Hedysarum, and provides supporting evidences for dividing Hedysarum into two subgenera, i.e. subgenus Hedysara and subgenus Ruticosa. |
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| Keywords: | Chemotaxonomy High-performance liquid chromatographic analysis |
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