Natural products from Tolpis barbata (L.) Gaertn. (Asteraceae,Cichorieae) |
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| Institution: | 1. Central Analítica - Centro de Apoio Multidisciplinar (CAM), Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;2. Centro de Biotecnologia da Amazônia, 69075-351, Manaus, AM, Brazil;3. Departamento de Química, Universidade Federal do Amazonas, 69077-000, Manaus, AM, Brazil;1. Department of Chemical, Geological, and Physical Sciences, Kwara State University, Malete, Nigeria;2. Department of Chemistry, Faculty of Science, University of Lagos, Lagos, Nigeria;4. Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;5. Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;6. Department of Forest Conversation and Protection, Forestry Research Institute of Nigeria, Jericho, Ibadan, Nigeria;1. Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, #1 Weigang, Nanjing, 210095, Jiangsu Province, PR China;2. College of Pharmacy, Shandong University of Traditional Chinese Medicine, #4655 Daxue Road, Jinan, 250355, Shandong Province, PR China;3. MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, PR China;4. Jiangsu Vocational College of Agricultural and Forestry, Zhenjiang, 212400, Jiangsu Province, PR China;1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China;2. National Institutes for Food and Drug Control, Beijing, 102629, China;3. Guangzhou Welman New Drug R&D CO., LTD, Guangzhou, 510620, China;4. School of Chinese Medicine, Hong Kong Baptist University, Hongkong, China;1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, 02115, MA, USA;2. Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Str. 4, 06120, Halle (Saale), Germany;3. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, 06120, Halle (Saale), Germany;4. Department of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, College of Health Sciences, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia |
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| Abstract: | One sesquiterpene lactone – 9α-hydroxy-3-deoxyzaluzanin C, three benzopyrans: desmethoxyencecalin (6-acetyl-2,2-dimethylchromene), desacetylripariochromen B and 6-(1-hydroxyethyl)-2,2-dimethylchromene, one coumarin – scopoletin and two eugenol derivatives were isolated from the roots of Tolpis barbata (L.) Gaertn, hitherto unexamined species. In the extract from aerial parts of the plant, five known phenolic compounds, namely: esculin, esculetin, chlorogenic acid (5-CQA), luteolin 7-O-glucoside and 3,5-dicaffeoylquinic acid (3,5-DCQA) were identified as major constituents. Except for the two coumarins – scopoletin and esculetin, which were previously obtained from Tolpis webbii Sch.Bip. and T. proustii Pit., the isolated and identified compounds have not been previously reported as constituents of Tolpis spp. Though benzopyrans were found in numerous species of the Asteraceae, their occurrence in the tribe Cichorieae has not been demonstrated before. |
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| Keywords: | Asteraceae Benzopyrans Phenolics Sesquiterpene lactone |
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