Vernoguinamide: A new ceramide and other compounds from the root of Vernonia guineensis Benth. and their chemophenetic significance |
| |
Institution: | 1. School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, 300072, China;2. National Herbarium of Georgia, Ilia State University, Tbilisi, Georgia;3. Institute of Botany, Armenian National Academy of Sciences, Yerevan, Armenia;4. New York Botanical Garden, Bronx, NY, USA;1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing, 100191, China;2. National Institutes for Food and Drug Control, Beijing, 102629, China;3. Guangzhou Welman New Drug R&D CO., LTD, Guangzhou, 510620, China;4. School of Chinese Medicine, Hong Kong Baptist University, Hongkong, China |
| |
Abstract: | The chemical investigation of the roots of Vernonia guineensis Benth. (Asteraceae) resulted in the isolation of a new ceramide, named vernoguinamide (1), together with fifteen known compounds, including three anthraquinones, physion (2), erythroglaucin (3) and emodin (4), three triterpenoids, hop-17(21)-en-3β-yl acetate (5), lupeol (6) and betulinic acid (7), six steroids, vernoguinoside A (8), vernoguinoside (9), β-sitosterol 3-O-β-D-glucoside (10), stigmasterol 3-O-β-D-glucoside (11), stigmasterol (12) and β-sitosterol (13) and three fatty acid derivatives, tetracosanoic acid (14), tricosanic acid (15) and arachidic acid glycerol ester (16). The structure of the new compound as well as those of the known compounds were established by spectrometric analysis including HRESI-MS, 1D and 2D-NMR and by comparison with the previously reported data. Among these compounds, the anthraquinones 2–4 and the triterpene 5 were isolated for the first time from Vernonia genus and compounds 6, 7 and 14–16 were extracted for the first time from the species. The isolated compounds were tested for their antibacterial activity and 3, 8 and 9 were the most active compounds against the tested bacteria. Furthermore, the chemophenetic relationships of the isolated compounds and their significance were also discussed. |
| |
Keywords: | Asteraceae Chemophenetic significance Ceramide Anthraquinone Antibacterial |
本文献已被 ScienceDirect 等数据库收录! |
|