首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Glucose Transporter 1, Distribution in the Brain and in Neural Disorders: Its Relationship With Transport of Neuroactive Drugs Through the Blood-Brain Barrier
Authors:Guo Xiuli  Geng Meiyu  Du Guanhua
Institution:(1) Department of Pharmacology, Marine Drug and Food Institute, Ocean University of China, Qingdao, 266003, China;(2) Department of Pharmacology, School of Pharmacy, Shandong University, Jinan, 250012, China;(3) Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, China
Abstract:Facilitative glucose transport is mediated by one or more of the members of the closely related glucose transporter (GLUT) family. Thirteen members of the GLUT family have been described thus far. GLUT1 is a widely expressed isoform that provides many cells with their basic glucose requirement. It is also the primary transporter across the blood-brain barrier. This review describes the distribution and expression of GLUT1 in brain in different pathophysiological conditions including Alzheimerrsquos disease, epilepsy, ischemia, or traumatic brain injury. Recent investigations show that GLUT1 mediates the transport of some neuroactive drugs, such as glycosylated neuropeptides, low molecular weight heparin, and d-glucose derivatives, across the blood-brain barrier as a delivery system. By utilizing such highly specific transport mechanisms, it should be possible to establish strategies to regulate the entry of candidate drugs.
Keywords:glucose transporter  distribution in brain  expression in brain disease  neuroactive drug  saccharide  blood-brain barrier
本文献已被 PubMed SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号