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Advances in preimplantation genetic diagnosis/screening |
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| Authors: | LiYing Yan Yuan Wei Jin Huang XiaoHui Zhu XiaoDan Shi Xi Xia Jie Yan CuiLing Lu Ying Lian Rong Li Ping Liu Jie Qiao |
| Institution: | 1. Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China 2. Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing, 100191, China 3. Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing, 100191, China |
| Abstract: | Preimplantation genetic diagnosis (PGD) gives couples who have a high risk of transmitting genetic disorders to their baby the chance to have a healthy offspring through embryo genetic analysis and selection. Preimplantation genetic screening (PGS) is an effective method to select euploid embryos that may prevent repeated implantation failure or miscarriage. However, how and to whom PGS should be provided is a controversial topic. The first successful case of PGD of a human being was reported in 1990, and there have been tremendous improvements in this technology since then. Both embryo biopsy and genetic technologies have been improved dramatically, which increase the accuracy and expand the indications of PGD/PGS. |
| Keywords: | preimplantation genetic diagnosis preimplantation genetic screening indications biopsy methods array comparative genomic hybridization next-generation sequencing |
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