MicroRNA in cell differentiation and development |
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Authors: | Yi Shi YouXin Jin |
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Institution: | (1) State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China |
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Abstract: | The regulation of gene expression by microRNAs (miRNAs) is a recently discovered pattern of gene regulation in animals and
plants. MiRNAs have been implicated in various aspects of animal development and cell differentiation, such as early embryonic
development, neuronal development, muscle development, and lymphocyte development, by the analysis of genetic deletions of
individual miRNAs in mammals. These studies show that miRNAs are key regulators in animal development and are potential causes
of human diseases. Here we review some recent discoveries about the functions of miRNAs in cell differentiation and development.
Supported by National Key Basic Research and Development Program of China (Grant No. 2005CB724602) and Knowledge Innovation
Project of the Chinese Academy of Sciences (Grant Nos. KSCX2-YW-R-096, KSCX1-YW-R-64) |
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Keywords: | miRNA embryonic development neuronal development muscle development lymphocyte development |
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