| Conservation of ribosomal protein gene ordering in 16 complete genomes |
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| 作者姓名： | 王宁 陈润生 王永雄 |
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| 作者单位： | WANG Ning,CHEN Runsheng(Protein Engineering Lab, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China);WANG Yongxiong(Department of Statistics, University of California at Los Angeles, CA 90095-1554, USA)
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| 摘 要： | The organization of ribosomal proteins in 16 prokaryotic genomes was studied as an example of comparative genome analyses of gene systems. Hypothetical ribosomal protein-containing operons were constructed. These operons also contained putative genes and other non-ribosomal genes. The correspondences among these genes across different organisms were clarified by sequence homology computations. In this way a cross tabulation of 70 ribosomal proteins genes was constructed. On average, these were organized into 9-14 operons in each genome. There were also 25 non-ribosomal or putative genes in these mainly ribosomal protein operons. Hence the table contains 95 genes in total. It was found that: (i) the conservation of the block of about 20 r-proteins in the L3 and L4 operons across almost the entire eubacteria and ar-chaebacteria is remarkable; (ii) some operons only belong to eubacteria or archaebacte-ria; (iii) although the ribosomal protein operons are highly conserved within domain, there are fine variat
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| 收稿时间： | 19 May 1999 |
Conservation of ribosomal protein gene ordering in 16 complete genomes |
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| Ning Wang,Runsheng Chen,Yongxiong Wang.Conservation of ribosomal protein gene ordering in 16 complete genomes[J].Science China Life sciences,2000,43(2):120-128. |
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| Authors: | Ning Wang Runsheng Chen Yongxiong Wang |
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| Institution: | (1) Protein Engineering Lab, Institute of Biophysics, Chinese Academy of Sciences, 100101 Beijing, China;(2) Department of Statistics, University of California at Los Angeles, 90095-1554, CA, USA |
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| Abstract: | The organization of ribosomal proteins in 16 prokaryotic genomes was studied as an example of comparative genome analyses of gene systems. Hypothetical ribosomal protein-containing operons were constructed. These operons also contained putative genes and other non-ribosomal genes. The correspondences among these genes across different organisms were clarified by sequence homology computations. In this way a cross tabulation of 70 ribosomal proteins genes was constructed. On average, these were organized into 9-14 operons in each genome. There were also 25 non-ribosomal or putative genes in these mainly ribosomal protein operons. Hence the table contains 95 genes in total. It was found that: (i) the conservation of the block of about 20 r-proteins in the L3 and L4 operons across almost the entire eubacteria and ar-chaebacteria is remarkable; (ii) some operons only belong to eubacteria or archaebacte-ria; (iii) although the ribosomal protein operons are highly conserved within domain, there are fine variations in some operons across different organisms within each domain, and these variations are informative on the evolutionary relations among the organisms. This method provides a new potential for studying the origin and evolution of old species. |
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| Keywords: | comparative genome analysis operon ribosomal proteins gene ordering |
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