Wound healing effects of methanol extract of Laurocerasus officinalis roem |
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| Authors: | S Ayla M E Okur M Y Günal E M Özdemir D Çiçek Polat A Yolta? |
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| Institution: | 1. Department of Histology and Embryology, School of Medicine, Istanbul Medipol University, ?stanbul, Turkey;2. Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey;3. Department of Pharmacology, Faculty of Pharmacy, University of Health Sciences, Istanbul, Turkey;4. Regenerative and Restorative Medicine Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey;5. Department of Physiology, School of Medicine, Alanya Alaaddin Keykubat University, Alanya, Turkey;6. Department of Animal Facility, Istanbul Medipol University, Istanbul, Turkey;7. Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara, Turkey;8. Department of Biology, Fundamental and Industrial Microbiology Division, Faculty of Science, Ege University, Bornova, Turkey |
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| Abstract: | Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using an excisional wound model model in mice. We used four groups of eight mice as follows: untreated (control), empty gel, extract + gel (L. officinalis + gel), and Madecassol® groups. All treatments were applied topically once daily. The scar area, percentage wound closure and epithelization time were measured. L. officinalis promoted wound healing and increased granulation tissue, epidermal regeneration and angiogenesis. L. officinalis extract, which is known for its antioxidant and antimicrobial activities, may be useful for promoting wound healing. |
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| Keywords: | Antimicrobial antioxidant extract Laurocerasus officinalis mice wound healing |
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