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Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking,MS/MS,and NMR
Institution:1. Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA;2. Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA 02118, USA;3. Department of Chemistry and Biochemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA;4. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA;5. Department of Biological Chemistry, Department of Chemistry, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA;6. Department of Surgery, Division of Neurosurgery, College of Medicine, University of Saskatchewan, Saskatoon, Canada
Abstract:
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  • Keywords:prion  NMR  mass spectrometry  cross-linking  patch clamp  ion channel  molecular dynamics  protein domain  copper  mutation
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