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Structural Insights into Stimulation of Ash1L's H3K36 Methyltransferase Activity through Mrg15 Binding
Authors:Peini Hou  Chang Huang  Chao-Pei Liu  Na Yang  Tianshu Yu  Yuxin Yin  Bing Zhu  Rui-Ming Xu
Institution:1. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;2. University of Chinese Academy of Sciences, Beijing 10049, China;3. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300353, China;4. Institute of Systems Biomedicine, Department of Pathology, School of Basic Medical Sciences, Peking-Tsinghua Center for Life Sciences, Peking University Health Science Center, Beijing 100191, China
Abstract:
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  • Keywords:crystal structure  Ash1L  Mrg15  histone  SET domain  methyltransferase  autoinhibitory loop
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