Transgenic animals as models for human disease |
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Authors: | Petters Robert M Sommer Jeffrey R |
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Institution: | (1) Department of Animal Science, North Carolina State University, USA |
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Abstract: | Transgenic animals, especially mice, have been used quite extensively as models for various human diseases. At first, the
level of scientific inquiry was driven by the need to establish the model. In many cases, these models may be considered quite
crude because of their limitations. More recently, transgenic models of disease have become more refined and are currently
being used to study the pathological mechanisms behind the disease rather than to just provide a model of the disease. Using
some examples from the recent literature, we will document the current level and complexity of inquiry using transgenic animals.
New techniques and techniques that may prove promising will be discussed.
This revised version was published online in August 2006 with corrections to the Cover Date. |
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Keywords: | transgenic animals models of disease homologous recombination |
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