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Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice |
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| Authors: | Rodolfo Ocadiz-Delgado Alberto Marroquin-Chavira Ruth Hernandez-Mote Concepción Valencia M Eugenia Manjarrez-Zavala Luis Covarrubias Patricio Gariglio |
| Institution: | 1. Department of Genetics & Molecular Biology, CINVESTAV-IPN Mexico, Av. IPN 2508. Colonia San Pedro Zacatenco, CP 07360, Mexico, DF, Mexico 2. Department of Pathology, Hospital Infantil de Mexico “Federico Gómez”, Mexico, Dr. Marquez 162. Col. Doctores, CP 06720, Mexico, DF, Mexico 3. Institute of Biotechnology-UNAM Mexico, Av. Universidad 2001. Col. Chamilpa, CP 62210, Cuernavaca, Morelos, Mexico 4. Instituto Nacional de Enfermedades Respiratorias (INER), Mexico, Calzada de Tlalpan 4502. Col. Sección XVI, CP 14080, Mexico, DF, Mexico |
| Abstract: | Squamous cell carcinoma (SCC) of the oral cavity is one of the most common neoplasms in the world. During the past 2 decades, the role of high-risk human papilloma virus (HR-HPV) has been studied and the data supporting HPV as a one of the causative agents in the development and progression of a sub-set of head and neck squamous cell carcinomas (HNSCC) has accumulated. In order to investigate the role of HR-HPV oncogene expression in early epithelial alterations in vivo, we produced transgenic mice expressing HPV16 early region genes from the promoter of the bovine keratin 6 gene (TgbK6-E6/E7]). In this article, we demonstrate that E6/E7 transgene was abundantly expressed and cellular proliferation was increased in the middle tongue epithelia of transgenic mice, and that in the same region young (27 weeks old) TgbK6-E6/E7] mice spontaneously developed histological alterations, mainly focal epithelial hyperplasia (FEH). |
| Keywords: | Tongue HPV Focal epithelial hyperplasia Proliferation Apoptosis |
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