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Two common nonsynonymous paraoxonase 1 (<Emphasis Type="Italic">PON1</Emphasis>) gene polymorphisms and brain astrocytoma and meningioma |
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| Authors: | Carmen Martínez José A Molina Hortensia Alonso-Navarro Félix J Jiménez-Jiménez José AG Agúndez Elena García-Martín |
| Institution: | 1.Department of Pharmacology & Psychiatry, Medical School,University of Extremadura,Badajoz,Spain;2.Service of Neurology,Hospital Doce de Octubre,Madrid,Spain;3.Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá,Alcalá de Henares,Madrid,Spain;4.Section of Neurology, Hospital "La Mancha-Centro",Alcázar de San Juan,Ciudad Real,Spain;5.Department of Biochemistry and Molecular Biology and Genetics,University of Extremadura,Badajoz,Spain |
| Abstract: | BackgroundHuman serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous PON1 polymorphisms and the risk of developing astrocytoma and meningioma. |
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