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疲劳性运动中线粒体电子漏引起质子漏增加
引用本文:时庆德,刘树森.疲劳性运动中线粒体电子漏引起质子漏增加[J].生物化学与生物物理学报,1999,31(1):97-100.
作者姓名:时庆德  刘树森
作者单位:[1]天津运动医学研究所 [2]中国科学院动物研究所生物膜与膜生物工程国家重点实验
摘    要:以大鼠递增强度力竭性竭性跑台运动为疲劳运动模型,观察了运动后大鼠骨骼肌线粒体电子漏和质子漏的变化。结果表明,运动性疲劳状态下大鼠骨骼肌线粒体超氧阴离子生成增加,脂质过氧线粒体质子漏增多是氧化磷酸化偶联程度下降的重要因素。实验结果支持电子漏引起质子漏的假说。

关 键 词:线粒体  氧化磷酸化  运动性疲劳  电子漏  质子漏

Electron Leak Causes Proton Leak in Skeletal Muscle Mitochondria in Exercise induced Fatigue
SHI Qing De,ZHANG Yong ,CHEN Jia Qi and LIU Shu Sen.Electron Leak Causes Proton Leak in Skeletal Muscle Mitochondria in Exercise induced Fatigue[J].Acta Biochimica et Biophysica Sinica,1999,31(1):97-100.
Authors:SHI Qing De  ZHANG Yong  CHEN Jia Qi and LIU Shu Sen
Institution:SHI Qing De,ZHANG Yong *,CHEN Jia Qi and LIU Shu Sen **
Abstract:Using an animal model of exercise induced fatigue by incremental exercise to exhaustion on a motor driven treadmill, the changes of the mitochondrial proton leak and electron leak in mitochondria of skeletal muscle from rats immediately after exhaustive exercise were observed. The results showed that, in exercise induced fatigue conditions, superoxide anions of rat skeletal muscle mitochondria increased;State 4 respiration rate significantly accelerated and respiration control ratio clearly decreased. Results show that, in the condition of exercise induced fatigue, the increased mitochondrial proton leak and electron leak may be important factors that cause the decrease in coupling of oxidative phosphorylation. Our results provide evidence supporting a hypothesis that electron leak causes proton leak in mitochondria.
Keywords:Mitochondria  oxidative phosphorylation  exercise  induced fatigue  electron leak  proton leak  
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