二聚化:受体酪氨酸激酶活化的重要机制

受体酪氨酸激酶家族是一类具有内源性蛋白酪氨酸激酶活性的生长因子受体。它们具有相似的分子结构 ,其配体介导的受体活化主要是通过二聚化的机制来实现的。配体介导同源或异源的受体二聚化 ,不同的配体以不同的机制介导受体的二聚化。本文介绍了受体酪氨酸激酶家族不同亚类受体在其配体介导下二聚化的机制 ,并着重介绍了表皮生长因子受体家族各成员间的异二聚化及其引起的胞内信号转导途径的多样化

Dimerization: A Key Mechanism of Receptor Tyrosine Kinase Activation

Receptor tyrosine kinase superfamily includes a group of growth factor receptors with intrinsic tyrosine kinase activity which share similar molecular structure. Their ligand induced activation is mediated primarily by the receptor dimerization. It was proposed that ligand induced homo or hetero dimerization is essential for the activation of receptor kinase; however, the mechanisms of receptor dimerization are different. This review introduces the ligand induced dimerization of different receptor tyrosine kinase subclasses and concentrates on heterodimerization between members of EGF receptor family, resulting the various cellular signaling pathways.