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Effects of Huangqi (Hex) on Inducing Cell Differentiation and Cell Death in K562 and HEL Cells
作者姓名:Cheng XD  Hou CH  Zhang XJ  Xie HY  Zhou WY  Yang L  Zhang SB  Qian RL
作者单位:Xiao-Dong CHENG1,Chun-Hui HOU1,Xue-Jun ZHANG2,Heng-Yue XIE1,Wei-Ying ZHOU1,Lei YANG2,Shu-Bing ZHANG1,and Ruo-Lan QIAN1 State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences,320 Yueyang Road,Shanghai 200031,China; Laboratory of Molecular Cell Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences,320 Yueyang Road Shanghai 200031,China the Chinese Academy of Sciences,320 Yueyang Road,Shanghai 200031,China
基金项目:This work was supported by the grants from the National Natural Science Foundation of China (No. 39893320,No. 39870378) and the Foundation of the Chinese Academy of Sciences (No. Kj 982-j1618)
摘    要:InterestintraditionalChineseherbalremedieshasboomedin the western countries. It is very important to study theirmolecular mechanisms and purify effective compoundswith new knowledge and new techniques to meet a greatneed for human health. Ephedrine, the f…

关 键 词:红白血病细胞系  人类  细胞死亡  细胞分化  黄芪  中药  癌症  分子机制

Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells
Cheng XD,Hou CH,Zhang XJ,Xie HY,Zhou WY,Yang L,Zhang SB,Qian RL.Effects of Huangqi (Hex) on inducing cell differentiation and cell death in K562 and HEL cells[J].Acta Biochimica et Biophysica Sinica,2004,36(3):211-217.
Authors:Cheng Xiao-Dong  Hou Chun-Hui  Zhang Xue-Jun  Xie Heng-Yue  Zhou Wei-Ying  Yang Lei  Zhang Shu-Bing  Qian Ruo-Lan
Institution:State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
Abstract:Huangqi (Astragalus membranaceus), a traditional Chinese medicine, has been used to ameliorate side effects of cancer chemotherapy in China. However, little is known about its molecular mechanisms. Here we show that induction of K562 or HEL cells with 1.5 mg/ml of Huangqi (Hex) (Components extracted from Huangqi) for 3-5 d results in the expression of beta-globin gene in both cell lines and leads to terminal differentiation. Moreover, the apoptosis in HEL cells can be induced by increasing concentration of Huangqi (Hex) to 4.5 mg/ml for 3-5 d. Upregulation of Apaf-1, caspase-3 and acetylcholinesterase (AChE) in HEL cells may play a crucial role in the process of apoptosis. The prospect of inducing expression of adult (beta) globin gene and apoptosis selectively in cancer cells is obviously attractive from a therapeutic point of view.
Keywords:cell death and differentiation  Huangqi (Hex)  human erythroleukemia cell lines  
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