| A Stable Upstream Stem-loop Structure Enhances Selection of the First 5'-ORF-AUG as a Main Start Codon for Translation Initiation of Human ACAT1 mRNA |
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| 作者姓名： | Li YANG Jiang CHEN Catherine C. Y. CHANG Xin-Ying YANG Zhen-Zhen WANG Ta-Yuan CHANG and Bo-Liang LI* State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences the Chinese Academy of Sciences Shanghai China |
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| 作者单位： | Li YANG，Jiang CHEN，Catherine C. Y. CHANG1，Xin-Ying YANG，Zhen-Zhen WANG，Ta-Yuan CHANG1，and Bo-Liang LI* State Key Laboratory of Molecular Biology，Institute of Biochemistry and Cell Biology，Shanghai Institutes for Biological Sciences，the Chinese Academy of Sciences，Shanghai 200031，China; Department of Biochemistry，Dartmouth Medical School，Hanover，NH 03756，USA 1 |
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| 基金项目： | This work was supported by the grants from the Major State Basic
Research Development Program of China (No. 2002CB513000)，the
National High Technology Research and Development Program of China
(2001AA221061) and the National Natural Science Foundat |
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| 摘 要： | Acyl-coenzyme A:cholesterol acyltransferase (ACAT)is an integral membrane protein, which is mainly locatedin rough endoplasmic reticulum (ER), and is responsiblefor catalyzing the intracellular formation of cholesterylester from cholesterol and long-chain fatty acyl-coenzymeA 1,2]. Human ACAT1 cDNA K1 was firstly cloned andfunctionally expressed in 1993 3]. Further studies withspecific anti-ACAT1 antibody (DM10) illustrated that onemajor 50 kD ACAT1 protein was expressed in various…
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A Stable Upstream Stem-loop Structure Enhances Selection of the First 5'-ORF-AUG as a Main Start Codon for Translation Initiation of Human ACAT1 mRNA |
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| Li YANG,Jiang CHEN,Catherine C. Y. CHANG,Xin-Ying YANG,Zhen-Zhen WANG,Ta-Yuan CHANG,and Bo-Liang LI* State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences,Shanghai ,China,.A Stable Upstream Stem-loop Structure Enhances Selection of the First 5''''-ORF-AUG as a Main Start Codon for Translation Initiation of Human ACAT1 mRNA[J].Acta Biochimica et Biophysica Sinica,2004(4). |
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| Authors: | Li YANG Jiang CHEN Catherine C Y CHANG Xin-Ying YANG Zhen-Zhen WANG Ta-Yuan CHANG and Bo-Liang LI State Key Laboratory of Molecular Biology |
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| Institution: | Li YANG,Jiang CHEN,Catherine C. Y. CHANG1,Xin-Ying YANG,Zhen-Zhen WANG,Ta-Yuan CHANG1,and Bo-Liang LI* State Key Laboratory of Molecular Biology,Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences,the Chinese Academy of Sciences,Shanghai 200031,China, Department of Biochemistry,Dartmouth Medical School,Hanover,NH 03756,USA 1 |
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| Abstract: | |
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| Keywords: | ACAT1 start codon Kozak sequence stem-loop structure |
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