Effect of polymyxin B on liposomal membranes derived from Escherichia coli lipids |
| |
Authors: | Masae Imai Keizo Inoue Shoshichi Nojima |
| |
Institution: | Department of Chemistry, National Institute of Health, Kamiosaki, Shinagawa-ku, Tokyo Japan |
| |
Abstract: | The specificity of the action of polymyxin B was studied using liposomes as a model membrane system. Liposomes prepared from total lipids of Gram-negative bacteria Escherichia coli, a mixture of purified E. coli phosphatidylethanolamine and cardiolipin and a mixture of phosphatidylethanolamine and phosphatidylglycerol, were extremely sensitive to polymyxin while those prepared from lipids of Gram-positive bacteria Streptococcus sanguis, lipids of sheep erythrocyte membranes, mixtures of egg lecithin and negatively charged amphiphatic molecules, were less sensitive to the action of the antibiotic. Chlolesterol was shown to suppress the polymyxin-induced response in liposomes. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|