The effects of hydrazine on sickle cells |
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| Authors: | Catherine Rice-Evans Savvas Omorphos Joseph M White |
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| Institution: | 1. Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, University of London, 8 Hunter Street, London, WC1N 1BP U.K.;2. Department of Haematology, King''s College Hospital Medical School, London SE 5 U.K. |
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| Abstract: | The response of the red cells from patients with sickle cell disease to hydrazine treatment in vitro is to inhibit the sickled morphology, while the metabolic characteristics and the osmotic fragility of the cells remain unaltered. However, the oxygen affinity of the sickle cell haemoglobin is decreased. |
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| Keywords: | Sickle cell Hydrazine |
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