| Quox-1基因同源序列在人胚早期发育中的表达 |
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| 引用本文： | 沈亦平,胡琦勇,王亚平,马晓军,黄诗笺,方慧兰,薛志刚.Quox-1基因同源序列在人胚早期发育中的表达[J].分子细胞生物学报,1997(1). |
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| 作者姓名： | 沈亦平 胡琦勇 王亚平 马晓军 黄诗笺 方慧兰 薛志刚 |
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| 作者单位： | 武汉大学生命科学学院，武汉大学生命科学学院，武汉大学生命科学学院，武汉大学生命科学学院，武汉大学生命科学学院，湖北省妇幼保健医院，法国法兰西学院细胞及分子胚胎学研究所 武汉 430072，武汉 430072，武汉 430072，武汉 430072，武汉 430072 |
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| 摘 要： | 以Quox-1基因的特异性片段b_2为探针,与人基因组DNA作Southern杂交,结果显示,人基因组中存在Quox-1基因的同源序列。以抗Quox-1蛋白的抗体与早期人胚胎组织的切片作免疫组化反应研究了Quox-1基因同源序列在人胚早期发育过程中的表达,结果表明其表达有明显的时间和空间特异性。胚龄30天以前,Quox-1基因的同源序列在人胚包括神经管等许多部位表达,30天以后表达部位局限于脊索、心肌细胞、生肌节、消化道上皮及周皮等处。文中讨论了Quox-1基因同源顺序对人类胚胎早期发育过程可能的调控作用。
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| 关 键 词： | Quox-1基因 同源异形框基因 基因表达 人胚胎发育 |
THE EXPRESSION OFQUOX-1 GENEHOMOLOGOUS SEQUENCE IN THE DEVELOPMENT OF EARLY HUMAN EMBRYOS |
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| SHEN Yi Ping HU Qi Yong WANG Ya Ping MA Xiao Jun,HUANG Shi Jian ZHANG Xi Yuan.THE EXPRESSION OFQUOX-1 GENEHOMOLOGOUS SEQUENCE IN THE DEVELOPMENT OF EARLY HUMAN EMBRYOS[J].Journal of Molecular Cell Biology,1997(1). |
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| Authors: | SHEN Yi Ping HU Qi Yong WANG Ya Ping MA Xiao Jun HUANG Shi Jian ZHANG Xi Yuan |
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| Abstract: | By using the b2 fragment of Quox-1 gene as probe, we have confirmed that the Quox-1 gene homologous sequence exists in the human genome according to the results of Southern blot. Studies on the expression of Quox-1 homologous sequence in early human embryos from 26 to 37 days by means of immunohistoche-mistry lechnigue with Quox-1 protein antibodies showed the spatiotemporal expre-
ssion patterns:in 26 days embryo Quox-1 homologous sequence was expressed in many places including neural tube, but 30 days later, tits expression sites were limited to notochord, digestive epithelium, myo-tome, cardiac muscle cell and periderm. The functions in control and regulation
of Quox-l gene homologous sequence during the early development of human
embryo were discussed. |
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| Keywords: | Quox-1 gene Homeobox genes Gene expression Human embryo development |
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