血卟啉衍生物对X线照射的HeLa细胞增敏效应

血卟啉衍生物(HpD)作为光敏剂与激光技术相结合应用于临床治疗浅表肿瘤已取得显著的疗效。但是,HpD能否作为辐射增敏剂治疗深部肿瘤亦已引起人们的重视。本文报告了离体培养的HeLa细胞经HpD(30微克/毫升)处理后接受X线(5 Gy)照射,观察其某些生物学特性的改变,并以此作为判断HpD的辐射增敏效应的指标。实验结果表明,HeLa细胞经HpD处理后可提高辐射敏感性(SER)10—67.7%。

BIOLOGICAL EFFECT OF HEMATOPORPHYRIN DERIVATIVE (HpD) AND X-RAY IRRADIATION ON HELA CELL

HpD could be utilized effectively asphotosensitizing agent with photodynamickilling action produced by laser irradiationin clinical application to treat superficialmalignancy,and usually got satisfactory re-sults in cases with proper indications.It isvery interesting if it can be used underionizing radiation for treatment of malignan-cy deeply situated. This thesis presents works on the cultu-red HeLa cell treated with HpD 30 tig/ml,then received 5 Gy X-ray irradiation andhad its biological activity modified,andenhanced the effect of ionizing irradiation,all these disclosed HpD rising up HeLa cellin vitro the sensitizing enhancement ratio(SER)from 10 to 67.7%.