Ontogenesis of gastrin cells in the pyloric antrum and duodenum of the mouse |
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Authors: | Prof Katsuko Kataoka Junko Miura Yasuko Takeoka Yoshisuke Kusumoto Noboru Yanaihara |
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Institution: | (1) Department of Anatomy, Hiroshima University School of Medicine, Hiroshima;(2) Biwako-Yoikuin Hospital, Otsu;(3) Laboratory of Bioorganic Chemistry, Shizuoka College of Pharmacy, Shizuoka, Japan;(4) Department of Anatomy, Hiroshima University School of Medicine, Kasumi 1-2-3, Minami-ku, 734 Hiroshima, Japan |
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Abstract: | Summary Ontogenesis of gastrin cells was studied in the pyloroduodenal mucosa of the mouse using anti-human G17 serum, R-1301, and anti-human G34(1–15) serum, R-2703. R-1301-immunostained cells first appeared in the pyloric mucosa of 14-day-old fetuses. Cells stained with both R-1301 and R-2703 appeared immediately after birth, and gradually increased in number to the adult level. Most R-1301-reactive cells were also reactive to R-2703, whereas some cells that reacted with R-1301 exhibited very weak or no reaction with R-2703. The discrepancy between these two immunoreactivities is discussed.In the duodenum, a considerable number of R-1301-reactive cells were present from the perinatal stage and through out adult development. A few R-2703-reactive cells were seen in the duodenum of young mice but not of the adult. |
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Keywords: | Gastrin cell Pyloric mucosa Ontogenesis Immunohistochemistry Mouse |
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