TRH-like immunoreactivity in endocrine cells and neurons in the gastro-intestinal tract of the rat and guinea pig |
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| Authors: | Yoshihiro Tsuruo Dr Tomas Hökfelt Theo J Visser Joe R Kimmel John C Brown A Verhofstadt J Walsh |
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| Institution: | (1) Department of Histology, Karolinska Institutet, Stockholm, Sweden;(2) Department of Medicine, Erasmus University, Rotterdam, The Netherlands;(3) Department of Biochemistry, University of Kansas Medical Center, Kansas City, KS, USA;(4) Medical Research Council of Canada Regulatory Peptide Group, University of British Columbia, Vancouver, B.C., Canada;(5) Department of Pathology, Catholic University, Nijmegen, The Netherlands;(6) Center for Ulcer Research and Education, University of California, Los Angeles, California, USA;(7) Department of Histology, Karolinska Institute, S-10401, P.O. Box 60400, Stockholm, Sweden |
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| Abstract: | Summary By use of the indirect immunofluorescence technique, the cellular localization of thyrotropin-releasing hormone (TRH) was studied in the gastrointestinal tract of rats and guinea pigs of different ages. TRH-like immunoreactivity (LI) was observed in many pancreatic islet cells of young rats and guinea pigs but only in single cells of 6-month-old rats. In aged guinea pigs, a reduction in the number of TRH-positive cells was evident; however, numerous strongly fluorescent cells were still present. In the guinea pig, TRH-LI was in addition observed in gastrin cells in the stomach. TRH-positive nerve fibers occurred in the myenteric plexus of the oesophagus, stomach and intestine of the rat, and in the muscle layers of the guinea pig. These results suggest a functional role of TRH both as hormone and neuroactive compound in various portions and sites of the gastro-intestinal tract of the rat and guinea pig |
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| Keywords: | Pancreas endocrine Stomach Intestine Immunohistochemistry Thyrotropin-releasing hormone (TRH) Somatostatin Avian pancreatic polypeptide Insulin Gastrin Rat Guinea pig |
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