The ACTH-interrenal axis in the freshwater stickleback,Gasterosteus aculeatus form leiurus |
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Authors: | Dr Michael Benjamin Michael P Ireland |
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Institution: | (1) Department of Zoology, University College of Wales, Aberystwyth, Wales;(2) Department of Cellular Biology and Histology, St. Mary's Hospital Medical School, W. 2. Paddington, London, England |
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Abstract: | Summary The ACTH-interrenal axis of the freshwater stickleback has been examined with the fish in a variety of physiological conditions. A morphometric analysis of ACTH cell ultrastructure in spring animals revealed that the only change from the winter condition was a significant decrease in the amount of perinuclear RER. The interrenal gland responded to metopirone treatment by an increase in both nuclear and cell size, although only a high dose of metopirone could degranulate the ACTH cells. Morphometry of the ACTH cells from metopirone-treated animals showed a significant increase in the amount of RER and a significant decrease in the number of free ribosomes and secretory granules, compared with control animals maintained in freshwater. Such ultrastructural changes may be expected of a cell that is stimulated to increase its secretion of polypeptide hormone. The ACTH-interrenal axis also responded to 70% seawater, as this treatment increased the interrenal cell and nuclear sizes. |
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Keywords: | ACTH-interrenal axis Freshwater stickleback Seasonal changes Metopirone Seawater adaptation Morphometry |
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