Effect of colchicine on lysosomal structures in maturation-ameloblasts of the rat incisor |
| |
| Authors: | A H Salama D R Eisenmann A E Zaki |
| |
| Institution: | (1) Oral Biology Department, Faculty of Oral and Dental Medicine, Cairo University, Egypt;(2) Department of Histology, College of Dentistry, University of Illinois at Chicago, USA;(3) College of Dentistry, University of Illinois at Chicago, 801 S. Paulina, 60612 Chicago, IL, USA |
| |
| Abstract: | Summary The lysosomal systems in maturation-ameloblasts affected by colchicine were examined using trimetaphosphatase cytochemistry. Demineralized segments of rat incisor were incubated for trimetaphosphatase. At all time intervals, lysosomal structures exhibited reduced enzyme reactivity and were clustered in the Golgi region of the cell. Both ruffle-ended and smooth-ended ameloblasts maintained essentially normal morphology up to 4 h after colchicine injection, except for some migration of organelles. After 8 h, the ruffled border was markedly modified and the associated dense granular material was no longer present. Changes in the lysosomal system and ruffled border indicate interference by colchicine with a putative resorptive function of the maturation-ameloblasts. |
| |
| Keywords: | Enamel Ameloblasts Colchicine Lysosomes Resorption Rat (Sprague-Dawley) |
| 本文献已被 SpringerLink 等数据库收录！ |
|
