Role of histamine and cyclic nucleotides in implantation in the rabbit |
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Authors: | Dr S K Dey C J Hubbard |
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Institution: | (1) Departments of Obstetrics and Gynecology and Physiology, Ralph L. Smith Research Center, Kansas University Medical Center, Kansas City, Kansas, USA;(2) Department of Obstetrics and Gynecology, The University of Kansas Medical Center, Ralph L. Smith Research Center, 66103 Kansas City, Kansas, USA |
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Abstract: | Summary The effect of histamine on cAMP and cGMP levels in day 6 (144 h post coitum) rabbit blastocysts was determined. Histamine at 200 M and 1000 M concentrations stimulated the increased formation of cAMP in vitro, whereas stimulation of cGMP occurred only in the presence of 1000 M histamine. Furthermore, intrauterine injection of RMI-12330A (50 g or 500 g/uterine horn), an inhibitor of adenylyl cyclase, on day 5 of pregnancy interrupted embryro development and implantation of the embryo. The drug was also effective in reducing the cAMP level in the endometrial cells in vitro. A relationship between histamine and cyclic nucleotide changes in embryo development and implantation is suggested. |
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Keywords: | Cyclic nucleotides Blastocyst Endometrium Implantation |
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