Chemical coding of neurons in the myenteric plexus and external muscle of the small and large intestine of the mouse |
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Authors: | Q Sang H M Young |
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Institution: | (1) Department of Anatomy and Cell Biology, University of Melbourne, Parkville, 3052, Victoria, Australia, AU |
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Abstract: | Immunohistochemical techniques were used to examine the presence and co-localisation of a range of putative neurotransmitters
and other neuronal markers in the myenteric plexus of the small and large intestine of the mouse. Distinct sub-populations
of myenteric neurons were identified, based on the combinations of substances they contained and the distribution of their
fibres. In the small intestine, there were two major classes of circular muscle motor neurons; one class was characterised
by the presence of nitric oxide synthase, vasoactive intestinal peptide plus neuropeptide Y (NOS/VIP/NPY), and the second
class contained calretinin plus substance P (CalR/SP). There were seven classes of neurons that innervated myenteric ganglia;
these contained NOS, VIP, NOS/VIP, NPY, CalR/calbindin (CalB), SP or 5-HT. In the large intestine, there were five major classes
of motor neurons that contained NOS, NOS/VIP, GABA, SP, or CalR/SP, and seven major classes of neurons that innervated myenteric
ganglia and contained NOS, VIP, CalR/CalB, CalR, SP, GABA or 5-HT. Although some aspects of the patterns of co-localisation
are similar to those in other species, this study re-inforces recent analyses that indicate significant species differences
in neurochemical patterns in the enteric neurons of different species.
Received: 28 August 1995 / Accepted: 30 November 1995 |
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Keywords: | : Enteric nervous system Immunohistochemistry Co-localisation Neuropeptides Calcium-binding proteins Nitric oxide synthase Mouse (BALB/c) |
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