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Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice
Authors:Andreas Cerny  Rolf M Zinkernagel  Peter Groscurth
Institution:(1) Department of Experimental Pathology, Institute of Pathology, University Hospital, Zürich, Switzerland;(2) Institute of Anatomy, Division of Cell Biology, University of Zürich-Irchel, Zürich, Switzerland;(3) Institute of Anatomy,Division of Cell Biology, University of Zürich-Irchel, CH-8057 Zürich, Switzerland
Abstract:Summary We have studied follicular dendritic cells (FDC) in lymph nodes of normal and thymus dysgeneic nude mice depleted of B-cells by chronic treatment with anti-IgM antibodies. We found that B cell depletion was accompanied by the absence of mature FDC as defined morphologically at the ultrastructural level. Only precursor FDC (p-FDC) could be demonstrated. Upon release of B-cell suppression, the repopulation of lymph nodes with B-cells was associated with the reappearance of fully differentiated FDC in primary follicles of nude mice and in secondary follicles of T-cell competent mice. We conclude that mature B-cells and/or B-cell products are required for the development of mature follicular dendritic cells in the mouse lymph node.
Keywords:Follicular dendritic cells  Lymph nodes  Electron microscopy  Nude mice
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