Changes in plasma phenylalanine, isoleucine, leucine, and valine are associated with significant changes in intracranial pressure and jugular venous oxygen saturation in patients with severe traumatic brain injury |
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| Authors: | Vuille-Dit-Bille Raphael N Ha-Huy Riem Stover John F |
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| Institution: | Surgical Intensive Care Medicine, Universit?tsSpital Zürich, Zurich, Switzerland. |
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| Abstract: | Changes in plasma aromatic amino acids (AAA?=?phenylalanine, tryptophan, tyrosine) and branched chain amino acids (BCAA?=?isoleucine, leucine, valine) levels possibly influencing intracranial pressure (ICP) and cerebral oxygen consumption (SjvO(2)) were investigated in 19 sedated patients up to 14?days following severe traumatic brain injury (TBI). Compared to 44 healthy volunteers, jugular venous plasma BCAA were significantly decreased by 35% (p?
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