Screening for Endophytic Fungi with Antitumour and Antifungal Activities from Chinese Medicinal Plants |
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| Authors: | Haiyan Li Chen Qing Yanli Zhang Zhiwei Zhao |
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| Affiliation: | (1) Laboratory for Conservation and Utilization of Bioresources, Yunnan University, 650091 Kunming, P.R. China;(2) Faculty of Biology and Chemistry Engineering, Kunming University of Science and Technology, 650093 Kunming, P.R. China;(3) The Yunnan Key Laboratory of Pharmacology for Natural Products Research, Kunming Medical College, 650031 Kunming, P.R. China |
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| Abstract: | Summary One hundred and thirty endophytic fungi isolated from 12 Chinese traditional medicinal plants collected at Yuanmou county and Dawei Mountain, Yunnan province, southwest China, were tested for antitumour and antifungal activities by MTT assay on human gastric tumour cell line BGC-823 and the growth inhibition test against 7 phytopathogenic fungi. The results showed that fermentation broths from 9.2% of the isolates exhibited antitumour activity and 30% exhibited antifungal activity, moreover, some of them exhibited broad-spectrum antifungal activity. The active isolates were identified to 32 taxa. The results indicate that the endophytic fungi of Chinese traditional medicinal plants are promising sources of novel bioactive compounds. |
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| Keywords: | Antifungal activity antitumour activity endophytic fungi medicinal plants |
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